November 21, 2020

FEATURED ARTICLE

Therapeutic Potential of B-1a Cells in COVID-19

"B-1a cells have been shown to ameliorate influenza virus infection, sepsis, and pneumonia, all of which are similar to COVID-19," says Monowar Aziz and colleagues in a new review article. "B-1a cell therapy is able to mitigate the progression of these infections to ARDS, raising the possibility that B-1a cell therapy may also ameliorate ARDS associated with COVID-19."

Corticosteroids in the Management of COVID-19

Get a summary of the current evidence supporting steroid therapy in the management of patients with acute respiratory distress syndrome and COVID-19 and key modifications for the pregnant patient.

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3 Properties of SARS-CoV-2 That Promote COVID-19

Many aspects of COVID-19 disease can be attributed to 3 main properties of the virus, which are listed and then explained in this review article.

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COVID-19 in Patients With Alcohol-Associated Hepatitis

Metabolic similarities and treatment challenges discussed

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Pelvic Floor Considerations in COVID-19

Because of the pervasive nature of this virus, pelvic floor physical therapists should be a part of the rehabilitation team treating these patients once they have become medically stable.

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Help Advance Our Understanding of COVID-19 — Publish Your COVID-19 Research in JCO Clinical Cancer Informatics

Oncologists and practitioners throughout the world are using applied clinical informatics to navigate the COVID-19 pandemic and care for patients with cancer.

STAY UPDATED BETWEEN WEEKLY BRIEFINGS

Below are our additional COVID-19 resources to keep you informed.

COVID-19 Briefing Archive

COVID-19 Resources on Ovid®

Wolters Kluwer COVID-19 Health Resources

COVID-19 Resources for Nurses

Evidence-based Risk Stratification for Sport Medicine Procedures During the COVID-19 Pandemic

Orthopaedic surgical procedures should consider COVID-19-associated risks and an assimilation of all available disease dependent, disease independent, and logistical information that is tailored to each patient, institution, and region. Using an evidence-based risk stratification of clinical urgency, we provide a framework for prioritization of orthopaedic sport medicine procedures that encompasses such factors. 

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Restarting Orthopaedic Care in a Pandemic: Ethical Framework and Case Examples

Article proposes ethical guidance for the resumption of care on the basis of public health ethics with a focus on clinical equipoise, triage tiers, and flexibility. We then provide orthopaedic surgery examples to guide physicians in the ethical resumption of care.

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Acute Appendicitis in Multisystem Inflammatory Syndrome in Children With COVID-19

In this Letter to the Editor, the authors present information on four children, 5- to 12-years-old with appendicitis and confirmed SARS-CoV-2. Three children were initially diagnosed with acute appendicitis and treated surgically and multisystem inflammatory syndrome in children (MIS-c) was diagnosed after appendectomies.

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Myocardial Injury in Severe COVID-19 Compared to Non-COVID Acute Respiratory Distress Syndrome

Knowledge gaps remain in the epidemiology and clinical implications of myocardial injury in COVID-19. The goal of this study was to determine the prevalence and outcomes of myocardial injury in severe COVID-19 compared to acute respiratory distress syndrome (ARDS) unrelated to COVID-19.

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Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection

Brain endothelial cells are susceptible to direct SARS-CoV-2 infection through flow-dependent expression of ACE2. Viral S protein binding triggers a unique gene expression profile in brain endothelia that may explain the association of SARS-CoV-2 infection with cerebrovascular events.

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